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| .:: RESEARCH ::. |
Typical hemolytic uremic syndrome (HUS):
Since 01.01.1997 a registry for patients with typical diarrhea associated HUS within the HUS-Net Study exists.
Aims of the study:
- Epidemiology of D+HUS cases including age at disease onset, pathogen and serotypes of Stx+ D+ HUS cases
- Cinical manifestation of the disease
- Treatment of the classical HUS
- 10-year-Follow-up for the discovery of long term sequelae
- Risk factors for long term sequelae
- Establishment of a comprehensive evidence based model for aHUS pathogenesis
Atypical hemolytic uremic syndrome (aHUS):
Within the HUS-Net Study we analyze genetic aspects and the Complement Systemin this severe kidney disease.
Aims of this study:
- genetic analysis of patients with aHUS
- Clinical course and outcome of the recurrent aHUS
- Identification and validation of genetic and acquired risk factors for aHUS
- Differentiation of subgroups within this disease
- Establishment of a comprehensive evidence based mode for aHUS pathogenesis
- Establishment of a "complement profile" as indication for an individualized pathogenesis depending therapy
- Prevention of endstage renal disease
- Possibility to perform a renal transplantation without recurrence within aHUS patients on dialysis
Publications:
Scheiring J, Rosales A, Zimmerhackl LB: Clinical practice. Today's understanding of the haemolytic uraemic syndrome. Eur J Pediatr.2010;167:7-13
Scheiring J, Andreoli SP, Zimmerhackl LB (2008) Treatment and outcome of Shiga-toxin-associated haemolytic uraemic syndrome (HUS). Pediatr Nephrol 2008; 23: 1749-1760.
Rosales A, Hofer J, Zimmerhackl LB. Complement regulation an atypical hemolytic uremic syndrome in children. Archivos latinamericanos de nefrologia pediatrica.2009.
Rosales A, Hofer J, Zimmerhackl LB. Complement regulation disorders and outcome after renal transplantation in patients with atypical hemolytic uremic syndrome. Sociedad iberoamericana de informacion cientifica, 2009.
Ariceta G, Besbas N, Johnson S, Karpman D, Landau D, Licht, Loirat C, Pecoraro C, Taylor CM, Van de Kar N, Vandewalle J, Zimmerhackl LB; Guidline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome. Pediatr Nephrol.2009;24.687-696.
Zimmerhackl LB, Scheiring J, Prufer F, Taylor CM, Loirat c. Renal transplantation in HUS patients with disorders of complement regulation. Pediatr Nephrol. 2007;22:10-16.
Prufer F, Scheiring J, Sautter S, Jensen DB, Treichl R, Wurzner R, Zimmerhackl LB: Terminal complement complex (C5b-9) in children with reccurent hemolytic uremic syndrome. Semin Thromb Hemost 2006;32:121-127.
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